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These updating methyl groups could be grouped into three regions, The hinge region attaching the GTPase and helical domains (Ile55, Val174), feature 3 (Leu232, Leu234) your sheets formed by 1, 3 and 4 (Ile184, Val201, Ile221, Ile253, Ile264). Although the methyl groups in direct exposure to the bound GDP were not identified in the analyses, the presence of the conformational exchange processes is suggested in the adjacent 1 1 loop (byproducts 41 45), Which is known as phosphate binding loop (P hook) And directly interacts with the bound GDP through amide phosphate friendships.
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