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By acquiring tubulin samples from species that radically differs in genetic signature [Porcine (neuro neuron), a persons (MCF 7 active cancer of the breast cell), Fungi26 (Agaricus bisporus mashroom) And facility (Six days old soybean germ lings)] We have experimentally determined the precise frequency domain that activates the protein molecules for a particular species.
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Tyrosine sulfation of these protein is catalyzed by tyrosylprotein sulfotransferases (TPSTs), which have been localized to the Golgi apparatus15, And this loan mod occurs in the trans Golgi as the final a static correction before secretion16. Tyrosine sulfation of secreted eIF5A strongly supports buying of its physiological function as an extracellular ligand.
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