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It has been suggested that recent ZIKV epidemics may be linked causally to a higher apparent transformative rate for the Asian genotype than the African genotype25, 26. bear in mind, Such comparisons are confounded by an inverse romance between the timescale of observation and estimated evolutionary rates27. Regression of sequence sampling dates against root to tip genetic distances suggests that molecular clock models can be applied reliably to the Asian ZIKV lineage (Fig. 2c, total Data Figs 2, 3). We estimate the whole genome transformative rate of Asian ZIKV to be 1.12103 alterations per site per year (95% Bayesian credible period (BCI) 0.97 1.27103), in step with other estimates for this lineage4, 26. We found no significant variations in evolutionary rates among ZIKV genome regions (fully extended Data Table 3a). the estimated ratio of divergence at nonsynonymous and synonymous sites (dN/dS) Of the Am ZIKV family tree is low (0.11, 95% encouragement interval 0.10 0.13), As looked at for other vector borne flaviviruses28, But is higher compared to PreAm ZIKV viruses (0.061, 0.047 0.077), Probably owing to the raised possibility of observing slightly deleterious changes in short term datasets, As observed during old epidemics29.
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