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Many biological processes were interested in mechanical stress, which included but were not limited to the recruitment of adapter proteins and the activation of protein kinases, just like extracellular signal related kinase (ERK), C Jun N incurable kinase (JNK), combined with p38. consequently, These kinases activate certain transcribing factors, Thereby bringing about changes in gene expression and metabolism29. Mechanical stress has also been reported in chondrocytes, But the previous study focused on the effects of biomechanical stress on the cell phenotype and ECM expression in human chondrocytes. The mechanisms by which mechanical stress regulates these changes are not fully understood but are likely interconnected your chondrocyte mechanical properties, Phenotype, And ECM had all been linked to the cytoskeleton structure30,31. Many studies have proposed a relationship between the cytoskeleton and biological phenotype from healthy classified cells to cancer cells32,33,34. these findings showed that both the elastic and viscoelastic properties of chondrocytes can jerseys wholesale mlb patches cheap be significantly altered by treatment with agents that disrupted or enhanced the structure of F actin microfilaments31,35. in turn, We presumed that mechanical stress can induce ECM expression by controlling the cytoskeleton arrangement and expression. alongside one another, Our results indicated that different cartilage regions indicated distinct morphologies and mechanical properties. what’s more, mechanized stress can affect the chondrocyte phenotype and alter the expression of chondrocyte ECM.
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